Rsearch-1.tif

 

Cell therapy

We are aiming to leverage biomolecular engineering, chemical engineering, and synthetic biology approaches to modify endogenous cells and endow them with targeting or therapeutic function for various diseases treatment. Particular interest will be focused on blood cells, stem cells, and immune cells.

 

Immunotherapy

We are interested in modulating the phenotype and function of immune cells through biomaterials-cell interaction or delivery of immunomodulatory agents for tissue engineering, cancer, and autoimmune disease treatment. Particular interest will be focused on the modulation of dendritic cells and macrophage, and the delivery of immune checkpoint inhibitors.

 

Personalized therapy

We are aiming to develop precision medicine through the delivery approach in combination with cell therapy and immunotherapy for personalized therapy to maximize treatment efficacy. Particular interest will be focused on neoantigen-based vaccination and microbiota research.

Highlighted Researches:

1. Quanyin Hu, Hongjun Li, Edikan Archibong, Qian Chen, Huitong Ruan, Sarah Ahn, Elena Dukhovlinova, Yang Kang, Di Wen, Gianpietro Dotti*,  Zhen Gu*. "Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets". Nature Biomedical Engineering, 2021. Link; News Reports

False-color SEM images.tif
CAR-T schematic.jpg

2. Quanyin Hu, Wujin Sun, Jinqiang Wang, Huitong Ruan, Xudong Zhang, Yanqi Ye, Song Shen, Chao Wang, Weiyue Lu, Ke Cheng, Gianpietro Dotti, Joshua F. Zeidner, Jun Wang, Zhen Gu*. "Conjugation of Haematopoietic Stem Cells and Platelets Decorated with Anti-PD-1 Antibodies Augments Anti-Leukaemia Efficacy". Nature Biomedical Engineering, 2, 2018. Link; News & Views

备份备份备份备份备份备份Scheme V15.tif

3. Quanyin Hu, Wujin Sun, Chenggen Qian, Chao Wang, Hunter Bomba, Zhen Gu*. “Anticancer Platelet-Mimicking Nanovehicles”. Advanced Materials, 27, 2015. Cover Featured. Link

PNAS-cdr.tif