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Cell therapy

We are aiming to leverage biomolecular engineering, chemical engineering, and synthetic biology approaches to modify endogenous cells and endow them with targeting or therapeutic function for various diseases treatment. Particular interest will be focused on blood cells, stem cells, and immune cells.

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Immunotherapy

We are interested in modulating the phenotype and function of immune cells through biomaterials-cell interaction or delivery of immunomodulatory agents for tissue engineering, cancer, and autoimmune disease treatment. Particular interest will be focused on the modulation of dendritic cells and macrophage, and the delivery of immune checkpoint inhibitors.

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Personalized therapy

We are aiming to develop precision medicine through the delivery approach in combination with cell therapy and immunotherapy for personalized therapy to maximize treatment efficacy. Particular interest will be focused on neoantigen-based vaccination and microbiota research.

Highlighted Research:

1. Jun Liu, Yixin Wang, William Heelan, Yu Chen, Zhaoting Li, Quanyin Hu*, "Mucoadhesive probiotic backpacks with ROS nanoscavengers enhance the bacteriotherapy for inflammatory bowel diseases", Science Advances, 8, eabp8798, 2022. DOI:10.1126/sciadv.abp8798

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2. Zhaoting Li, Fanyi Mo, Yixin Wang, Wen Li, Yu Chen, Jun Liu, Ting-Jing Chen-Mayfield, Quanyin Hu*, "Enhancing Gasdermin-induced tumor pyroptosis through preventing ESCRT-dependent cell membrane repair augments antitumor immune response", Nature Communications, 13, 6321, 2022. DOI: 10.1038/s41467-022-34036-8

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3. Chen Chen#, Weiqiang Jing#, Yu Chen, Ganyu Wang, Mohnad Abdalla, Lin Gao, Maosen Han, Chongdeng Shi, Anning Li, Peng Sun, Xin Jiang, Zhenmei Yang, Shengchang Zhang, Jing Zhang, Chunwei Tang, Ying Liu, Rui Zhang, Fengbo Xu, Baixiang Dong, Xueen Li, Minglu Liu, Bangming Qiang, Yanhua Sun, Xia Wei, Jun Li, Quanyin Hu*, Xinyi Jiang*, "Intracavity generation of glioma stem cell–specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy",  Science Translational Medicine, 14, eabn1128, 2022. DOI: 10.1126/scitranslmed.abn1128

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4. Zhaoting Li#, Yingyue Ding#, Jun Liu, Jason Wang, Luna Mo, Yixin Wang, Paul Sondel, Seungpyo Hong, Quanyin Hu*. "Depletion of tumor associated macrophages enhances local and systemic platelet-mediated anti-PD-1 delivery for post-surgery tumor recurrence treatment", 13, 1845, 2022. Nature Communications. DOI: doi.org/10.1038/s41467-022-29388-0

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5. Quanyin Hu, Hongjun Li, Edikan Archibong, Qian Chen, Huitong Ruan, Sarah Ahn, Elena Dukhovlinova, Yang Kang, Di Wen, Gianpietro Dotti*,  Zhen Gu*. "Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets". Nature Biomedical Engineering, 2021. Link; News Reports
 

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6. Quanyin Hu, Wujin Sun, Jinqiang Wang, Huitong Ruan, Xudong Zhang, Yanqi Ye, Song Shen, Chao Wang, Weiyue Lu, Ke Cheng, Gianpietro Dotti, Joshua F. Zeidner, Jun Wang, Zhen Gu*. "Conjugation of Haematopoietic Stem Cells and Platelets Decorated with Anti-PD-1 Antibodies Augments Anti-Leukaemia Efficacy". Nature Biomedical Engineering, 2, 2018. Link; News & Views

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7. Quanyin Hu, Wujin Sun, Chenggen Qian, Chao Wang, Hunter Bomba, Zhen Gu*. “Anticancer Platelet-Mimicking Nanovehicles”. Advanced Materials, 27, 2015. Cover Featured. Link

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