We are aiming to leverage biomolecular engineering, chemical engineering, and synthetic biology approaches to modify endogenous cells and endow them with targeting or therapeutic function for various diseases treatment. Particular interest will be focused on blood cells, stem cells, and immune cells.
We are interested in modulating the phenotype and function of immune cells through biomaterials-cell interaction or delivery of immunomodulatory agents for tissue engineering, cancer, and autoimmune disease treatment. Particular interest will be focused on the modulation of dendritic cells and macrophage, and the delivery of immune checkpoint inhibitors.
We are aiming to develop precision medicine through the delivery approach in combination with cell therapy and immunotherapy for personalized therapy to maximize treatment efficacy. Particular interest will be focused on neoantigen-based vaccination and microbiota research.
1. Jun Liu, Yixin Wang, William Heelan, Yu Chen, Zhaoting Li, Quanyin Hu*, "Mucoadhesive probiotic backpacks with ROS nanoscavengers enhance the bacteriotherapy for inflammatory bowel diseases", Science Advances, 8, eabp8798, 2022. DOI:10.1126/sciadv.abp8798
2. Zhaoting Li, Fanyi Mo, Yixin Wang, Wen Li, Yu Chen, Jun Liu, Ting-Jing Chen-Mayfield, Quanyin Hu*, "Enhancing Gasdermin-induced tumor pyroptosis through preventing ESCRT-dependent cell membrane repair augments antitumor immune response", Nature Communications, 13, 6321, 2022. DOI: 10.1038/s41467-022-34036-8
3. Chen Chen#, Weiqiang Jing#, Yu Chen, Ganyu Wang, Mohnad Abdalla, Lin Gao, Maosen Han, Chongdeng Shi, Anning Li, Peng Sun, Xin Jiang, Zhenmei Yang, Shengchang Zhang, Jing Zhang, Chunwei Tang, Ying Liu, Rui Zhang, Fengbo Xu, Baixiang Dong, Xueen Li, Minglu Liu, Bangming Qiang, Yanhua Sun, Xia Wei, Jun Li, Quanyin Hu*, Xinyi Jiang*, "Intracavity generation of glioma stem cell–specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy", Science Translational Medicine, 14, eabn1128, 2022. DOI: 10.1126/scitranslmed.abn1128